With Multi N/C 2100S analyzer from Analytikjena, established the method for calibrating total organic carbon (TOC) analyzer. In addition to the parameters in TOC analyzer procedures (JJG821-2005), 4 indexes were added in the method, including zero drift, linearity, correlation with standard curve and examination limit. At the same time, the determination of accuracy was changed. According to the use frequency and stability of apparatus, it is suggested that the calibrating cycle should not be over 2 years.