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空气微粒子典型暴露人群肺结节与多环芳烃的关联研究 |
秦艳兰1, 陈忠礼2, 邵迎2, 贾茜1, 蔡祖艾3, 秦志豪2, 赵爽1, 夏娟1, 李彦1
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1.重庆大学附属三峡医院健康管理中心;2.重庆大学三峡库区生态环境教育部重点实验室;3.重庆大学附属三峡医院肿瘤中心
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摘要: |
为探索重庆万州区城区空气典型暴露人群肺结节与多环芳烃的关联。于2022年4月至2023年11月征集重庆市万州区40名交通警察进行问卷调查和血液样本采集。分析了23项生化指标,进行胸部低剂量CT(LDCT)检查。使用GC-MS检测血清中16种多环芳烃。以LDCT报告结果分为有无肺结节两组,比较两组人群生化指标、血清多环芳烃浓度的差异。采用多因素Logistic回归分析确定与肺结节的显著相关的多环芳烃种类。40例参与研究人员中,检出肺结节29例(72.50%),其中孤立性肺结节5例(12.5%),多发性肺结节24例(60%);微小结节22例(55%),小结节7例(17.5%);按照LU-RADS 分类:2类结节12例(30%),3类结节16例(60%),4类结节1例(2.5%)。肺结节组血清中苊 (Acenaphthene)、荧蒽 (Fluoranthene)的浓度显著高于无肺结节组(p<0.05)。Logistic回归分析及稳健性分析结果均显示,血清荧蒽浓度升高显著增加了肺结节的发病风险(p<0.05)。 |
关键词: 多环芳烃 肺结节 影响因素 |
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基金项目:重庆市万州区科卫联合医学科研项目重点项目 |
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Study on the association between pulmonary nodules and polycyclic aromatic hydrocarbons in people with typical exposure to air particulates |
Chen Zhongli1, Shao Ying1, Jia Qian2, Cai Zuai3, Qin Zhihao1, Zhao Shuang2, Xia Juan2
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1.Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment, Chongqing University;2.Department of Health Management, Chongqing University Three Gorges Hospital;3.Department of Cancer Center, Chongqing University Three Gorges Hospital
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Abstract: |
To explore the association between pulmonary nodules and polycyclic aromatic hydrocarbons in people with typical air pollution exposure in Wanzhou District, Chongqing. From April 2022 to November 2023, 40 traffic police officers in Wanzhou District, Chongqing were recruited to conduct questionnaire surveys and blood sample collection. Twenty-three biochemical indicators were analyzed and chest low-dose CT (LDCT) examination was performed. GC-MS was used to detect 16 types of polycyclic aromatic hydrocarbons in serum. Based on the LDCT report results, the patients were divided into two groups with and without pulmonary nodules, and the differences in biochemical indicators and serum PAH concentrations between the two groups were compared. Multivariate logistic regression analysis was used to determine the PAH types that were significantly associated with pulmonary nodules. Among the 40 participants in the study, 29 cases (72.50%) of pulmonary nodules were detected, including 5 cases (12.5%) of solitary pulmonary nodules, 24 cases (60%) of multiple pulmonary nodules, and 22 cases of micronodules ( 55%), 7 cases (17.5%) of small nodules; according to LU-RADS classification: 12 cases (30%) of type 2 nodules, 16 cases (60%) of type 3 nodules, 1 case (2.5%) of type 4 nodules %). The concentrations of acenaphthene and fluoranthene in the serum of the pulmonary nodule group were significantly higher than those of the non-pulmonary nodule group (p<0.05). Logistic regression analysis and robustness analysis showed that fluoranthene was significantly positively correlated with the occurrence of pulmonary nodules (p< 0.05). |
Key words: polycyclic aromatic hydrocarbons, influencing factors of pulmonary nodules |