| 摘要: |
| 目的 以血清铁浓度与γ射线之间的剂量-效应关系实验文献为依据，尝试研究血清铜浓度与γ射线之间的剂量-效应关系；方法 以小鼠为实验模型，采用不同剂量γ射线辐照小鼠，采用5-Br-PADAP比色法检测小鼠照后不同时间点的血清铜浓度，建立血清铜浓度与辐照剂量的剂量-效应关系；使用建立的剂量-效应关系估算小鼠生物剂量并与双盲剂量进行比较。结果 血清铜浓度与辐照剂量成反比，采用该剂量-效应关系估算的小鼠生物剂量与双盲剂量结果接近。结论 血清铜可作为辐照标志物用于本实验条件下小鼠的辐照剂量的重建。 |
| 关键词: 血清铜，γ射线，剂量-效应，小鼠 |
| DOI： |
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| Feasibility Study of Biological Dosimeter Based on Serum Copper |
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MIN Xuanyu
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China Nuclear Energy Technology Co
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| Abstract: |
| Objective To study the dose-effect relationship between serum copper concentration and γ-rays based on the experimental literature on the dose-effect relationship between serum iron concentration and γ-rays. Methods The mice were used as the experimental model, and the mice were irradiated with different doses of γ-rays. The serum copper concentration of mice at different time points after irradiation was detected by 5-Br-PADAP colorimetry, and the dose-effect relationship between serum copper concentration and irradiation dose was established. The biological dose of mice was estimated using the established dose-effect relationship and compared with the double-blind dose. Results The serum copper concentration was inversely proportional to the irradiation dose, and the biological dose estimated by the dose-effect relationship was close to the double-blind dose. Conclusion Serum copper can be used as a radiation marker for the reconstruction of radiation dose in mice under the experimental conditions. |
| Key words: Serum copper, γ-ray, Dosage-effect ,Mice |
