引用本文:尹燕敏.超高效液相色谱三重四级杆质谱联用法测定水中的氯霉素[J].环境监控与预警,2013,5(5):26-28
YIN Yan min.Determination of Chloramphenicol in Water Samples by Solid Phase Extraction Ultra Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry[J].Environmental Monitoring and Forewarning,2013,5(5):26-28
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超高效液相色谱三重四级杆质谱联用法测定水中的氯霉素
尹燕敏
苏州市环境监测中心站
摘要:
超高效液相色谱三重四级杆质谱联用法同时测定水中痕量的氯霉素残留,该方法采用电喷雾电离源、多重反应监测负离子模式在5min内完成对氯霉素的分析,方法检出限为0.2ng/L,空白样品和实际样品的加标回收率为76.2%~104%,该方法具有操作简便,灵敏度高,重现性好的特点。
关键词:  氯霉素  液质联用  固相萃取
DOI:
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基金项目:江苏省环境监测基金(1006)
Determination of Chloramphenicol in Water Samples by Solid Phase Extraction Ultra Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry
YIN Yan min
Abstract:
A rapid analytical method for chloramphenicol (CAP) in water samples was developed. Water samples were purified and concentrated by solid phase extraction (SPE) then detected by ultra performance liquid chromatographyelectrospray tandem massspectrometry (UPLC〖CD2〗MS/MS).The method used electrospray ionization, multiple reactions monitoring in negative ion mode to analyze CAP residue qualitatively and quantitatively. The analysis of CAP products can be finished in 5 minutes. The limit of determination of this method was 0.2ng/L. The average recovery rate of real samples was in the range of 76.2%~104%. This method was simple, sensitive and good repeatability.
Key words:  chloramphenicol  UPLC-MS/MS  SPE