引用本文:曾超,蒋科伟,钱佳,周季堂,刘敏敏.固相萃取-液质联用分析药物和个人护理品[J].环境监控与预警,2016,8(5):34-37
ZENG Chao, JIANG Ke wei, QIAN Jia, ZHOU Ji tang, LIU Min min.Determination of Pharmaceutical and Personal Care Products by Solid Phase Extraction Coupled with LC/MS[J].Environmental Monitoring and Forewarning,2016,8(5):34-37
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固相萃取-液质联用分析药物和个人护理品
曾超,蒋科伟,钱佳,周季堂,刘敏敏
作者单位
曾超1,蒋科伟2,钱佳1,周季堂1,刘敏敏1* 1. 江苏中宜金大分析检测有限公司 江苏 宜兴 2142002. 宜兴市环境监测站江苏 宜兴 214200 
摘要:
建立了固相萃取-液质联用分析药物和个人护理品(PPCP<sup>s</sup>)的方法,采用Oasis HLB固相萃取柱分别在酸性条件下和碱性条件下对PPCP<sup>s</sup>进行富集提取,该法对于宜兴地区能够检出的30种PPCP<sup>s</sup>均具有良好的线性,相关系数为0.990~0.999,检出限为1.37~10.12ng/L。应用该法对宜兴地区地表水中存在的PPCP<sup>s</sup>进行分析,结果显示30种PPCPs均有不同程度检出,分布最广泛的7种分别为避蚊胺、阿替洛尔、对乙酰氨基酚、普鲁卡因、β-雌二醇、卡马西平和苯佐卡因,阿替洛尔浓度较高,普遍为5~600ng/L。避蚊胺虽然出现频率最高,但其在各个采样点浓度偏低,普遍为1~50 ng/L。
关键词:  药物  个人护理品  宜兴  固相萃取-液质联用
DOI:
分类号:X832;O657.63
文献标识码:B
基金项目:
Determination of Pharmaceutical and Personal Care Products by Solid Phase Extraction Coupled with LC/MS
ZENG Chao, JIANG Ke wei, QIAN Jia, ZHOU Ji tang, LIU Min min
Abstract:
A method for determination of pharmaceutical and personal care products (PPCP<sup>s</sup>) was developed using solid phase extraction liquid chromatography/mass spectrometry (SPE LC/MS). The PPCP<sup>s</sup> were concentrated by Oasis HLB solid phase extraction column at acidic and alkaline conditions. Thirty PPCP<sup>s</sup> were detected in Yixing City by the developed method with the correlation coefficient in the range of 0.990~0.999 and the detection limit in the range of 1.37~10.12 ng/L. The most frequently detected PPCP<sup>s</sup> were diethyltoluamede, atenolol, paracetamol, procaine, beta estradiol, carbamazepine and benzocaine. Atenolol had the highest concentration of these PPCP<sup>s</sup> with the range of 500~600 ng/L. Diethyltoluamede was the most frequently discovered PPCPs , however, the concentrations were low with the range of 1~50 ng/L
Key words:  Pharmaceuticals  Personal care  Yixing City  SPE LC/MS