| 摘要: |
| 综述了糖皮质激素受体干扰物的作用机制和生态效应，列举了多种活性筛选方法，并根据性质对干扰物进行了种类的划分。在当前环境糖皮质激素受体干扰物研究的基础上，指出了作用机制的研究不全面、个体生物筛选方法匮乏、缺少可信的活性模拟预测技术等问题，并提出了应借助模式生物完善作用机制研究，在此基础上建立稳定、高通量的个体生物活性筛选方法和动力学过程模拟替代技术用以活性预测等发展方向。 |
| 关键词: 糖皮质激素 受体干扰 作用机制 活性筛选 内分泌 |
| DOI： |
| 分类号:X18 |
| 文献标识码:A |
| 基金项目:国家自然科学基金资助项目（21577058；21307054）；江苏省自然科学基金青年资助项目（BK20130551）；〖JP〗国家环保部公益性行业科研专项基金资助项目（201409040）；国家水体污染控制与治理重大专项基金资助项目（2012ZX07101-003） |
|
| Study Progress of Environmental Contaminants with Glucocorticoid Receptor（GR）-disrupting Activities |
|
SHEN Yanhong， SHI Wei， YU Hongxia
|
|
State Key Laboratory of Pollution Control and Resource Reuse， School of the Environment， Nanjing University， Nanjing， Jiangsu 210023， China
|
| Abstract: |
| The mechanism of action and ecological effects of GR disrupting chemicals were reviewed in this paper. Moreover， different methods for GR activity screening were summarized and disrupting chemicals were classified. On the basis of current studies on GR disrupting chemicals， knowledge gaps were identified， which include the further elucidation of mechanism， the development of in vivo screening methods and the prediction of GR disrupting activities. According to these， there is a need to obtain more information on model organisms. Furthermore， establishing the stable high throughput in vivo screening methods and optimizing computational simulation based on molecular dynamic process to generate reliable data for minimum cost should be taken into account in the future research. |
| Key words: Glucocorticoid Receptor disrupting Mechanism of action GR activity screening Endocrine |
