| 摘要: |
| 简述了液相色谱串联高分辨质谱（LC-HRMS）的优势和其在水环境监测领域中的实际工作流程。分析了LC-HRMS在水环境监测应用中面临的数据库储备相对匮乏和优先锁定定性目标相对滞后的问题，提出，通过建立目标化合物数据库，从厂家或供应商处购买与仪器匹配的数据库，建立高通量靶向监测和高通量非靶向筛查的体制机制，以及建立具有地方特色的特征污染物数据库等几种方式，以期进一步提高鉴别工作效率，更好地满足水环境监测的筛查需求。 |
| 关键词: 液相色谱 高分辨质谱 水环境监测 |
| DOI： |
| 分类号:X832;O657.63 |
| 文献标识码:B |
| 基金项目:江苏省环保科研基金资助项目（2017024）；江苏省环境工程重点实验室开放基金资助项目（ZX2017006） |
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| Application of Liquid Chromatography Coupled with High Resolution Mass Spectrometry in Water Environment Monitoring |
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ZHOU Xu，WU Dan，HUANG Bi yuan，LING Hong，HUANG Xia yin
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Jiangsu Provincial Key Laboratory of Environmental Engineering，Jiangsu Provincial Academy of Environmental Science，Nanjing，Jiangsu 210036，China
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| Abstract: |
| The advantages of liquid chromatography high resolution mass spectrometry (LC-HRMS) and its practical workflow in water environment monitoring are summarized in this article. The problems confronting the application of LC-HRMS for water monitoring are the shortage of database and lag of prior locking on qualitative targets. It is proposed to establish the corresponding databases, identify the target peaks of qualitative screening, share data resources, establish and perfect the system mechanism of high throughput targeted monitoring and high throughput non targeted screening, by building target chemical databases, purchasing databases that match the instruments from a manufacturer or supplier,and building a characteristic contaminant database with local features, so as to improve the efficiency of the identification process further, and meet the needs of water environmental monitoring. |
| Key words: Liquid chromatography High resolution mass spectrometry Water environment monitoring |
