引用本文:石子悦,刘旺,黄莹,刘阳,梁雪芳.酚类抗氧化剂及其代谢产物对鱼类的毒性研究进展[J].环境监控与预警,2020,12(5):51-59
SHI Zi-yue, LIU Wang, HUANG Ying, LIU Yang, LIANG Xue-fang.Research Progress on the Toxicity of Synthetic Phenolic Antioxidants and Their Metabolites to Fish[J].Environmental Monitoring and Forewarning,2020,12(5):51-59
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酚类抗氧化剂及其代谢产物对鱼类的毒性研究进展
石子悦,刘旺,黄莹,刘阳,梁雪芳
作者单位
石子悦,刘旺,黄莹,刘阳,梁雪芳* 内蒙古大学生态与环境学院内蒙古自治区环境污染控制与废物资源化重点实验室,内蒙古 呼和浩特 010021 
摘要:
简述了水环境中合成酚类抗氧化剂(SPAs)及其代谢产物,SPAs对鱼类的急性毒性效应、发育毒性效应及机制、内分泌干扰毒性效应和机制,以及代谢过程和产物毒性预测。指出,为准确实现对SPAs及其代谢物的化学品管理及生态风险评估,未来研究应聚焦于对合成酚类抗氧化剂及其代谢物在水生生物体内的分布及浓度检测,为该类化合物的生物富集和生物转化研究提供更多的背景资料;开展对SPAs潜在毒性分子机制的研究,并建立起分子水平上的毒理学效应与个体乃至种群水平上的不良后果之间的联系;探究并完善SPAs的代谢机制,并对现已明确的代谢产物(如BHT-Q)开展毒性效应评价。
关键词:  合成酚类抗氧化剂  代谢产物  发育毒性  内分泌干扰效应  鱼类
DOI:
分类号:X503.225;TQ314
文献标识码:A
基金项目:国家自然科学基金资助项目(21866024); 内蒙古自治区自然科学基金资助项目(2020MS02003); 内蒙古自治区高校青年科技英才计划基金资助项目(NJYT-20-B01)
Research Progress on the Toxicity of Synthetic Phenolic Antioxidants and Their Metabolites to Fish
SHI Zi-yue, LIU Wang, HUANG Ying, LIU Yang, LIANG Xue-fang
Abstract:
The acute toxic effects, developmental and endocrine disrupting toxic effects and mechanisms of synthetic phenolic antioxidants (SPAs) and their metabolites in aquatic environment on fish, as well as metabolic process and product toxicity prediction were briefly described. It pointed out that we should focus on the detection and the distribution of concentration of synthetic phenolic antioxidants and their metabolites in aquatic organisms in the future in order to accurately realize the chemical management and ecological risk assessment of SPAs and their metabolites, so as to provide more background information for the study of bioenrichment and biotransformation of these compounds. Besides, it is necessary to research the molecular mechanisms of the potential toxicity of SPAs and to establish the relationship between the toxicological effects at the molecular level and the adverse consequences at the individual or even population level, also, it is necessary to explore and improve the metabolic mechanism of SPAs and to evaluate the toxic effects of established metabolites (such as BHT Q).
Key words:  SPAs  Metabolites  Development toxicity  Eendocrine disrupting effects  Fish