|关键词: 细颗粒物 化学组分 炎症机制 信号通路 细胞自噬
|Research Progress on Pollution Status, Health Effects and Inflammatory Mechanisms of PM2.5 in the Atmosphere
WANG Jia，JIANG Shou-fang，LIU Ran，DING Zhen1,2,3
1. School of Public Health, Southeast University, Nanjing, Jiangsu 210009,China;2. School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210,China;3. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009,China
|Air fine particulate matter (PM2.5) pollution has become an important factor affecting human health, and its health effects and inflammatory mechanisms have been widely concerned by people. This article briefly describes the pollution status at home and abroad. The harm to human health was systematically expounded in terms of the chemical components of PM2.5. In addition, the toxic mechanism of PM2.5 causing body inflammation was summarized and discussed from two aspects of signal pathway and autophagy, so as to provide the corresponding scientific reference basis for the follow up research and control of the harm of atmospheric particulate matter to body health.
|Key words: PM2.5 Chemical composition Inflammatory mechanism Signal pathway Autophagy