引用本文:王佳,蒋守芳,刘冉,丁震.大气中PM2.5污染现状、健康效应及其致炎症机制研究进展[J].环境监控与预警,2021,13(5):31-37
WANG Jia,JIANG Shou-fang,LIU Ran,DING Zhen.Research Progress on Pollution Status, Health Effects and Inflammatory Mechanisms of PM2.5 in the Atmosphere[J].Environmental Monitoring and Forewarning,2021,13(5):31-37
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大气中PM2.5污染现状、健康效应及其致炎症机制研究进展
王佳,蒋守芳,刘冉,丁震1,2,3
1. 东南大学公共卫生学院,江苏 南京 210009;2. 华北理工大学公共卫生学院,河北 唐山 063210;3. 江苏省疾病预防控制中心,江苏 南京 210009
摘要:
空气细颗粒物(PM2.5)污染已成为影响人体健康的重要因素,其健康效应及致炎症机制已经受到人们的广泛关注。简述了PM2.5国内外污染现状,从PM2.5的质量浓度和组成成分2个方面系统地阐述了其对人体健康的危害,并重点从介导信号通路和介导细胞自噬2个方面对PM2.5导致机体炎症反应的毒性机制进行了总结和讨论,为后续研究和控制PM2.5对机体健康的危害提供科学参考。
关键词:  细颗粒物  化学组分  炎症机制  信号通路  细胞自噬
DOI:
分类号:X823
基金项目:国家自然科学基金资助项目(81872579)
Research Progress on Pollution Status, Health Effects and Inflammatory Mechanisms of PM2.5 in the Atmosphere
WANG Jia,JIANG Shou-fang,LIU Ran,DING Zhen1,2,3
1. School of Public Health, Southeast University, Nanjing, Jiangsu 210009,China;2. School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210,China;3. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009,China
Abstract:
Air fine particulate matter (PM2.5) pollution has become an important factor affecting human health, and its health effects and inflammatory mechanisms have been widely concerned by people. This article briefly describes the pollution status at home and abroad. The harm to human health was systematically expounded in terms of the chemical components of PM2.5. In addition, the toxic mechanism of PM2.5 causing body inflammation was summarized and discussed from two aspects of signal pathway and autophagy, so as to provide the corresponding scientific reference basis for the follow up research and control of the harm of atmospheric particulate matter to body health.
Key words:  PM2.5  Chemical composition  Inflammatory mechanism  Signal pathway  Autophagy